Pentapeptide-18 (Leuphasyl) – 200MG

Pentapeptide-18 (Leuphasyl)

Pentapeptide-18 is a synthetically manufactured anti-wrinkle peptide comprising of five amino acids (H-Tyr-Ala-Gly-Phe-Leu-OH) that was designed to replicate the biological action of blocking nerve signals responsible for muscle contractions, ultimately diminishing wrinkling at the stratum corneum. According to scientists, pentapeptide-18 may bind on the skin's neuroreceptors and could provide a muscle contraction-modulating effect by hindering the production of acetylcholine, a neurotransmitter responsible for muscle contractions.

There are also some suggestions that pentapeptide-18 can affect skin cell functioning. It could be beneficial in increasing skin barrier elasticity, as it takes part in the stimulation of critical proteins collagen and elastin. Both of these proteins are an important part of the extracellular matrix of the skin and production tends to slow down with age.

A study in 2014 showed the potential of PENTAPEPTIDE-18 (Leuphasyl) in reducing the thickness and width of wrinkles and furrows at the level of the stratum corneum. ObjectiveThis study investigated the efficacy of a Pentapeptide-18 formulation on moderate to severe wrinkles, after twice daily application for 28 days. ConclusionIt was found that wrinkle depth diminished by 11.31% on average thanks to digital imaging and silicone replicas. The authors write, in the study supported by Anca O. Dragomirescu et al., "Leuphasyl is an active synthesis peptide ... Despite its evident inferior efficiency to botulinum toxin ... it [may be] free from side effects and it confers an aspect of wrinkles' attenuation."

In fact, studies suggest that Pentapeptide-18 might be particularly specific. Some clinical studies have suggested a 2-9% reduction in appearance of wrinkles. A double-blind, placebo-controlled study assessed skin imaging and dermatological and self-rated measures of wrinkle depth and smoothness in response to various peptides. In conclusion, the results indicated a general decrease with respect to wrinkle depth and improved smoothness of skin after four weeks.

Park et al. Delving deep into examining the potential activities of D-tyrosine-containing cosmetic Pentapeptide-18 derivatives on melanogenesis Qazi (2020) Modifications to these peptides consisted of replacing N-terminal L-tyrosine with D-tyrosine or adding L/D-tyrosine at the C-terminal. These potential hypotheses are studied here using melanoma MNT-1 cells. These suggest that modifications in the structure of the peptide could modify melanogenesis. Proof of principle that the presence of D-tyrosine, specifically situated at C-terminal of lower peptide chain may lead to effective and safe depigmenting compound. This activity was particularly visible in Pentapeptide-18 analogs appended with C-terminal D-tyrosine. The results suggest that the position and orientation of the tyrosine residues in peptide may have an important impact. Racemic D-tyrosine (opposite enantiomer of natural L-tyrosine) could thus theoretically affect how the peptide interacts with enzyme/receptor in melanin producing background, hence implying melanin formation suppression capability by the cells.

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