Syn-AKE – 200MG

$212.00

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Size 200MG
Form Lyophilized powder
Purity 99%
Contents Syn-AKE

Syn-AKE

Tripeptide-3 is a synthetic peptide (Syn-AKE = beta-alanyl-L-prolyl-3-aminomethyl-L-alanine benzyl amide acetic acid). Syn-AKE is a peptide that's consisted of the amino acids alanine, proline, and diamino butyrate bonded together by peptide bonds. The same holds true for the peptide that was modeled after Waglerin-1(a polypeptide). Waglerin-1 is a muscle relaxant that inhibits acetylcholine from the neuromuscular junction, thereby reducing muscle contractions.

The researchers who created Syn-AKE were trying to create a peptide with Waglerin-1-like activity on muscle contractions. The mechanism of action that the peptide is supposed to work by is a temporary inhibition of muscle contractions which in turn should result in a reduction in wrinkle depth on the skin of test subjects. This is why this compound has been well studied for decades as an anti-aging supplement (reducing fine lines and wrinkles, improving skin texture, and increasing skin hydration) for the skin in insects JUST by wrinkle-relaxing.

The researchers have reported that Syn-AKE mimics the action of Waglerin-1. Waglerin-1 is known as a muscle-relaxant. Typically, this component is a 22-amino acid polypeptide, and may selectively target a particular form of nicotinic acetylcholine receptors (nAChRs). The nACh receptors transmit signals from nerves to muscles, and make the muscle contractions. Waglerin-1 seems to block the release of acetylcholine by inhibiting nictone acetylcholine receptors (nAChRs), and hence blocks muscle contraction. Waglerin-1 is also believed to act as a modulator of the gamma-aminobutyric acid (GABA) receptors of the brain. Although, the modulation of these receptors plays a significant role in controlling the activity of neurons and interference with them by Waglerin-1 can engender substantial hazards under research conditions.

However, these are not known risks of Waglerin-1 and early research indicates Syn-AKE is unable to penetrate the blood-brain barrier effectively or impact GABA receptors in the central nervous system (CNS). Syn-AKE was produced to imitate the action of Waglerin-1 by inhibiting the same nAChRs on the neuromuscular junctions. More recently, a tripeptide known as Syn-AKE was designed by mimicking the amino acid sequence in the region of Waglerin-1 that binds to nAChRs.

It is believed that Syn-AKE can penetrate the skin well and interact with the nAChRs in the muscles located just below it, perhaps inhibiting their response to acetylcholine on-the-fly. According to researchers, the peptide is an important tool against expression lines as it relaxes facial muscles. Experimental research of the peptide determined that it "was able to reduce both innervated muscle cell contraction rate (...) by 82 % (...) and acetylcholine release [2 h] after presentation."

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