Palmitoyl Tetrapeptide-7 – 200MG
$184.00
Discount per Quantity
Quantity | Discount | Price |
---|---|---|
5 - 8 | 5% | $174.80 |
9 + | 10% | $165.60 |
Palmitoyl Tetrapeptide-7
Palmitoyl Tetrapeptide-7 is a four amino acid peptide bound to palmitic fatty acid (palmitoyl-lysine-threonine-treonine-lysine-serin) consisting of glycine, glutamine, and arginine. It is a synthetic peptide analogue of the naturally occurring matrikine peptide that has been identified as an important regulator of extracellular matrix (ECM) turnover and other cell-mediated activities.
The Palmitoyl Tetrapeptide-7 peptide has been found in preliminary studies to boost collagen, elastin, and extracellular matrix (ECM) component synthesis, and has even be shown to suppress pro-inflammatory cytokines. It has also been proposed to regulate gene expression in the ECM remodeling, cell proliferation and inflammation.
Additionally, Palmitoyl Tetrapeptide-7 may work to inhibit the activity of interleukin-6 (IL-6), a pro-inflammatory cytokine associated with skin cell apoptosis (cell aging and death) as well as inflammation. Increased secretion of IL-6 which is assumed to degrade the ECM and combined results in increasing the rigidity and reducing plastic nature as well structural integrity of skin barrier.
Only in animal studies have materials such as Palmitoyl Tetrapeptide-7 been suggested to possibly inhibit the activity of matrix metalloproteinases (MMPs) within animal models. MMPs are a group of enzymes and might degrade ECMs proteins in the normal course of tissue growth. Might prevent ECM damange via downregulation of MMP activity, hence allow cells to repair and maintain the ECM. The more exact breakdown is that this peptide might induce the synthesis of important constituents from skin extracellular matrix, such laminin IV and V as well collagen VII. Laminins are suggested to play an important role for the structural stability and integrity of the basement membrane, and collagen VII is assumed mandatory for anchoring fibrils which tether dermis with the epidermis. As Palmitoyl Tetrapeptide-7 has the ability to improve the production of these molecules, the skin tissue resilience could potentially be improved subsequent to the repair and maintenance of a healthy skin barrier. They also think the peptide might lower secretion of IL-6, a cytokine widely suspected to drive inflammation. Palmitoyl Tetrapeptide-7 may thereby decrease inflammation, particularly post-UVB exposure, believed to induce inflammatory responses in the skin; by reducing IL-6.
Again, Palmitoyl Tetrapeptide-7 may especially hone in on increasing collagen type VII as discussed. Collagen type VII is suggested to be an essential structural components of skin tissues, playing a major role in stabilising the architecture of dermal-epidermal junction. It is believed to have a major role in anchoring the fibrils that bind the outer epidermis to the underlying dermis. This collagen could constitute an important component of the basement membrane, acting as a support for holding these skin layers together. Although it is known that the lack of degradation of this connection in the dermo-epidermal junction leads to blistering disorders and thus collagen type VII are consideer as fundamental for preventing hoof wall separation. Additionally, collagen type VII might be contributing in the skin tissue repair process. This form of collagen may have important implications in the healing and repair of skin, by perhaps promoting epidermal reattachment to underlying tissue following an injury. They speculate that increasing collagen VII synthesis may improve healing outcomes, especially in aged or disease-compromised dermal settings.
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