GHK Basic (Tripeptide-1) – 200MG

GHK Basic (Tripeptide-1)

GHK Basic is a Tripeptide glycine-histidine-lysine, A naturally occurring tripeptide found in plasma, urine, saliva and other fluids. GHK is made by numerous cell types, including but not limited to fibroblasts, monocytes and macrophages. It is also an abundant component of platelets and expressed by various types of cells, including in the liver and brain. Since GHK is a copper-binding peptide, it is possible that GHK can modulate multiple biological events such as. wound healing, tissue repair and the immune response in this context.

GHK has also been postulated to play a role in the regulation of ion channels, enzymes, receptors and gene expression. It seems that the GHK levels fluctuate during cell lifespan and it has been proposed that these changes affect cell aging. This can lead to decreased recovery and immune function. GHK is a potential stimulator of collagen synthesis and has demonstrated the ability to promote wound healing and cellular functions in skin cells. In addition, there is epidemiological evidence that GHK can also be a potent antioxidant and anti-inflammatory.

Here is study - a cutaneous healing application for GHK. A clinical study used GHK, together with its copperbound version, in animal models of diabetic neuropathic ulcers. Wound models GHK showed ulcer closure was enhanced over vehicle when the wounds were put under a wound care protocol. A greater proportion of larger plantar ulcers were significantly more likely to completely close and fewer GHK treated ulcers became infected. The scientists pointed out that the "incidence of ulcer infections was much lower (7% incidence vs 34%) in the plantar ulcers treated immediately after debridement."

Further, animal studies showed the healing efficiency of GHK in accelerated would healing as well. In another study, the effects of GHK on wound healing were compared to control (without GHK-treated) wounds in rabbits. The wounds were assessed every day and on days 7, 14, 21, 28 planimetry was performed to evaluate the area of non-healed wound and the percentage of total healed wound. The GHK group showed significantly more number of neutrophils and vessel counts than the control group. The researchers suggested that the peptide could speed up wound healing and granulation, where new connective tissue and tiny vessels that form in the surfaces of a wound during repair. One proposed mechanism is that this may produce a rise in the activity of antioxidant enzymes (proteins which help protect cells against oxidative stress damage). Moreover, there could be a betterment in the stage of neo-vascularization where neovascularization is considered as an essential process for wound healing involves the formation and growth of new blood vessels inside the wound to supply with nutrients and oxygen that aid tissue repair.

A further study, which also focussed on the effects of GHK in enhancing ischemic open wound healing in rats. The wound area of the GHK group seemed to be significantly smaller than that of the control group. GHK-treated wounds had less of the pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha), matrix metalloproteinase-2 (MMP-2), and matrix metalloproteinase-9 (MMP-9). All of these markers are related to mechanisms of inflammation and tissue remodeling, suggesting GHK may modulate inflammatory gene expression to prevent tissue damage in ischemic wound beds.

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