Decapeptide-12 – 200MG

Decapeptide-12

Decapeptide-12 is a small (10 amino acid) synthetic peptide. The developers of Decapeptide-12 have speculated on the possibility that this may exist because some of the research suggested that it might be able to inhibit melanin production in the skin by slowing down melanin synthesis by inhibiting tyrosinase, an enzyme involved in producing melanin.

Decapeptide-12 has no structural similarity to any naturally occurring peptide. Instead, it was engineered and manufactured to have particular characteristics. Decapeptide-12 is studied most for its ability to decrease melanin production and hyperpigmentation. It is also under investigation for potential effects on cell growth, differentiation, and the reduction of cellular aging. However, further studies are warranted in order to elucidate the potential biocharacteristics and outputs of Decapeptide-12 experiments in these settings.

As previously elaborated, Decapeptide-12 is speculated to function largely by suppressing melanin production known as melanogenesis. Melanin synthesis has been proposed as a multi-step process that could take place within melanocytes, the specialized skin cells. In this pathway, tyrosinase is thought to play a critical role given that it acts in the first two steps of melanogenesis, catalyzing the hydroxylation of tyrosine to DOPA (3,4-dihydroxyphenylalanine) and the oxidation of DOPA to DOPAquinone. These conversions have been proposed to be required as intermediates for the eventual generation of eumelanin and pheomelanin, which are the two primary forms of melanin pigments that determine skin, hair, and eye color and could provide UV radiation protection. As discussed above, Decapeptide-12 seems to work as a tyrosinase activity inhibitor. Though the exact molecular pathways at which Decapeptide-12 acts are convoluted and comprised of multiple steps, a general description is that this compound may have an ability to bind to certain binding helices of tyrosinase enzyme or its mRNA and reduce the rate of enzymatic catalysis in some of these essential reactions by melanin synthesis. This could be due to a direct interaction with the enzyme, altering its conformation and lowering its catalytic efficacy. Decapeptide-12 may also inhibit the gene expression of the enzyme that would result in reduced functional tyrosinase available to melanocytes.

A clinical case study in dark skin (Fitzpatrick skin type IV) suggested that Decapeptide-12 could potentially expedite post-inflammatory hyperpigmentation clearance more than placebo. The authors hypothesize that this effect might be mediated by the tyrosinase-inhibiting activity of Decapeptide-12.

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