GHK Basic – 50MG

GHK Basic

GHK Basic is made up of a tripeptide (that is, a molecule) that consists of three amino acids: glycyl, histidyl and lysine. This short-chain peptide helps your cells to communicate on various actions.

Studies on GHK revealed various potential biological activities, such as the induction of blood vessel and nerve outgrowth, improvement in elastin, glycosaminoglycan, collagen synthesis and significant increase of dermal fibroblast functions. This peptide shows benefit in tissue repair has been documented and researched in both lung connective tissue, bone tissue, liver, stomach lining as also skin.

The peptide is also purported to play a role in DNA repair and lung protection, fibroblast activation, as well as possibly act as an inhibitor on proinflammtory and pro-aging molecules such as NFκB; it has even been suggested that GHK Basic could potentially help repair skin barrier protective proteins.

Prior animal model studies have found that the peptide may work via two principles to induce wound healing. First, GHK along with a high-concentration helium-neon laser was shown to increase rates of wound contraction and granulation tissue production in the murine model in association with increased activities of antioxidant enzymes and blood vessel neovascularization. Second, a study in diabetic and CONTROL murine wound healing reported that collagen dressing alone increased the rate of wound healing, and GHK-loaded gels had an even larger effect28. According to the researchers, “the wounds were completely closed at 99.39% when [exposed to] biotinylated GHK-loaded films on day 21 as compared to the wound closure of 69.49% for plain films.” Increased in wound glutathione, epidermal ascorbic acid, epithelialization and collagen synthesis - fibroblasts - and mast cell activation.

Interestingly, GHK and its analogs could possibly be of benefit in stimulation and growth of follicles as well. The researchers previously reported that the naturally occurring copper complex GHK-Cu could increase vascular endothelial growth factor production, which likely is a first step in promoting growth and new blood vessel formation. In fact, the copper-containing version of GHK that has been tested in mice seemed to produce a significant reduction in wound area compared to placebo. There were suggestions that wounds treated with the copper-containing variant of GHK may have experienced lower levels of pro-inflammatory markers, as shown by shear zone concentrations of MMP-2, MMP-9, and TNF-alpha.

Importantly, the copper-containing forms of GHK might additionally minimise certain local variables that may stymie wound healing including but not limited to encouragement of wound colonisation with pathogenic microorganisms. For example, a study on the influence of GHK on healing diabetic ulcers concluded that the peptide improved wound closure in larger size ulcers (Holcomb K. et al. The researchers noted that "whereas the improvement in wound closure was greater (median 89.2% versus −10.3% for vehicle; P < 0.01) in larger plantar ulcers (>100 mm2 at study entry). The prevalence of ulcer infections was likewise significantly reduced, at 7 % in GHK against 34% for vehicle.

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