CJC-1295 (Mod GRF 1-29) & Ipamorelin - 10MG

CJC-1295 (Mod GRF 1-29) & Ipamorelin – 10MG

(51 customer reviews)

$87.00

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Discount per Quantity

QuantityDiscountPrice
5 - 85%$82.65
9 +10%$78.30
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Size 10MG
Form Lyophilized powder
Purity 99%
Contents CJC-1295 NO DAC (5MG) / Ipamorelin (5MG)

Scientific Overview of CJC-1295 & Ipamorelin Peptide Blend

CJC-1295 & Ipamorelin are synthetic peptides studied for their interactions with the growth hormone (GH) axis. Ipamorelin has been explored as a selective growth hormone secretagogue, functioning through ghrelin receptor pathways. CJC-1295, also referred to as Mod GRF 1-29, has been investigated as an analog of somatocrinin, with potential to stimulate growth hormone-releasing hormone (GHRH) receptors. Research suggests that when combined, these two peptides may influence GH regulation through complementary mechanisms.

Alternative Names: CJC-1295: Mod GRF 1-29, Ipamorelin: NNC 26-0161

CJC-1295 & Ipamorelin Studies and Research Data

Research on Gastric Function and Ipamorelin

Studies indicate that Ipamorelin may contribute to gastrointestinal activity by interacting with ghrelin receptors. Experimental data suggest it may accelerate gastric emptying and support contractility of gastric smooth muscle under certain conditions. In rodent models, researchers noted a potential increase in food intake, body weight, and fat distribution associated with Ipamorelin, as well as changes in serum leptin levels that may be linked to appetite regulation.

CJC-1295 and Pituitary Pathways

CJC-1295 has been studied for its possible binding to GHRH receptors on pituitary cells. Findings suggest this interaction may trigger signal cascades involving second messengers such as cAMP, leading to downstream transcriptional activity related to GH synthesis. Observations in murine models of GHRH gene ablation point to possible normalization of growth indicators, including body weight, bone length, and lean mass, with concurrent increases in pituitary RNA and GH mRNA levels.

Combined Research on CJC-1295 & Ipamorelin

When introduced together, CJC-1295 and Ipamorelin may influence GH regulation through distinct yet complementary pathways. Ipamorelin appears to elevate baseline GH secretion, while CJC-1295 may sustain pulsatile activity. This interaction has been hypothesized to contribute to changes in nitrogen balance and protein metabolism. Studies suggest Ipamorelin may reduce hepatic urea synthesis during catabolic states, potentially normalizing nitrogen distribution across tissues. The different pharmacokinetics of the two peptides—Ipamorelin with a shorter half-life and CJC-1295 with a longer one—may contribute to both rapid and sustained activity in experimental systems.

Conclusion

Research on CJC-1295 and Ipamorelin highlights their potential roles in modulating growth hormone pathways. Ipamorelin has been studied for its selective interaction with ghrelin receptors, particularly in digestive and metabolic processes, while CJC-1295 has been investigated for its influence on pituitary-driven GH synthesis. When combined, they may operate synergistically, offering a model for studying both immediate and longer-term regulation of GH activity.

References

  1. Alba M, Fintini D, Sagazio A, Lawrence B, Castaigne JP, Frohman LA, Salvatori R. Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1290-4. doi: 10.1152/ajpendo.00201.2006. Epub 2006 Jul 5. PMID: 16822960.
  2. Martin, B., Lopez de Maturana, R., Brenneman, R., Walent, T., Mattson, M. P., & Maudsley, S. (2005). Class II G protein-coupled receptors and their ligands in neuronal function and protection. Neuromolecular medicine, 7(1-2), 3–36. https://doi.org/10.1385/nmm:7:1-2:003
  3. Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab. 2006 Mar;91(3):799-805. doi: 10.1210/jc.2005-1536. Epub 2005 Dec 13. PMID: 16352683.
  4. Lall, S., Tung, L. Y., Ohlsson, C., Jansson, J. O., & Dickson, S. L. (2001). Growth hormone (GH)-independent stimulation of adiposity by GH secretagogues. Biochemical and biophysical research communications, 280(1), 132–138. https://doi.org/10.1006/bbrc.2000.4065
  5. Ionescu, M., & Frohman, L. A. (2006). Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog. The Journal of clinical endocrinology and metabolism, 91(12), 4792–4797. https://doi.org/10.1210/jc.2006-1702
  6. Aagaard, N. K., Grøfte, T., Greisen, J., Malmlöf, K., Johansen, P. B., Grønbaek, H., Ørskov, H., Tygstrup, N., & Vilstrup, H. (2009). Growth hormone and growth hormone secretagogue effects on nitrogen balance and urea synthesis in steroid treated rats. Growth hormone & IGF research, 19(5), 426–431. https://doi.org/10.1016/j.ghir.2009.01.001
  7. Greenwood-Van Meerveld, B., Tyler, K., Mohammadi, E., & Pietra, C. (2012). Efficacy of ipamorelin, a ghrelin mimetic, on gastric dysmotility in a rodent model of postoperative ileus. Journal of experimental pharmacology, 4, 149–155. https://doi.org/10.2147/JEP.S35396
  8. Venkova K, Mann W, Nelson R, Greenwood-Van Meerveld B. Efficacy of ipamorelin, a novel ghrelin mimetic, in a rodent model of postoperative ileus. J Pharmacol Exp Ther. 2009 Jun;329(3):1110-6. doi: 10.1124/jpet.108.149211. Epub 2009 Mar 16. PMID: 19289567.
  9. Raun K, Hansen BS, Johansen NL, Thøgersen H, Madsen K, Ankersen M, Andersen PH. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998 Nov;139(5):552-61. doi: 10.1530/eje.0.1390552. PMID: 9849822.
  10. Newton, A. C., Bootman, M. D., & Scott, J. D. (2016). Second Messengers. Cold Spring Harbor perspectives in biology, 8(8), a005926. https://doi.org/10.1101/cshperspect.a005926
  11. Sinha DK, Balasubramanian A, Tatem AJ, Rivera-Mirabal J, Yu J, Kovac J, Pastuszak AW, Lipshultz LI. Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males. Transl Androl Urol. 2020 Mar;9(Suppl 2):S149-S159. doi: 10.21037/tau.2019.11.30. PMID: 32257855; PMCID: PMC7108996.

Disclaimer:
The products mentioned are intended solely for laboratory research and in-vitro experimentation. They are not approved for human or animal use of any kind. All details provided are for educational purposes only. By purchasing from this site, you agree to comply with our Terms and Conditions.

Certificate of Analysis - CJC-1295 & Ipamorelin Blend

High Performance Liquid Chromatography - CJC-1295 & Ipamorelin Blend

Mass Spectrometry - CJC-1295 & Ipamorelin Blend

51 reviews for CJC-1295 (Mod GRF 1-29) & Ipamorelin – 10MG

  1. James Connel –

  2. Billy –

  3. bryan A –

  4. Sky –

  5. lab –

  6. melody W –

    Happy with teverything

  7. Eddie –

  8. alexander S –

    GREATTTTTTTTTTTT

  9. michael P –

    Good

  10. Will Cox –

    Good stuff.

  11. bryan C –

    I love this peptide, results are great

  12. courtney R –

  13. jim –

  14. ezavala –

  15. deanna R –

  16. johnson E –

  17. daniel W –

    Helpful support made the process easy.

  18. Howard B –

  19. Jose D –

    Packaging could have been sturdier, but acceptable.

  20. lauren James –

    PACKAGING WAS SECURE, DELIVERY ON TIME.

  21. Jacobie E –

  22. jamie O –

    Great

  23. Marietta j –

    GHSH are the way of the future for research honestly.

  24. howen arden –

    I’m a happy camper

  25. Richard –

    great experience ordering here

  26. rhonda W –

    Raw Amino t certificates of analysis with every

  27. Neo C –

    I had a minor issue with my order and the service team resolved it the same day. They offered a clear explanation, refunded the shipping fee, and arranged a replacement without any hassle.

  28. Crystal J –

    Purity levels are outstanding. Easy to order, shipped quickly 👍

  29. Maze 5 –

  30. Christopher 1 –

  31. roy ayers –

  32. William schultz –

    Raw Amino, thanks so much for providing detailed certificates of analysis for each lot. That transparency reassured me about the integrity of the product and helps build trust.

  33. Mars 1 –

  34. lsanchez1 –

  35. Jacob471 –

  36. JJ29 –

  37. Jolin124 –

    Good that they are open and transparent with info.

  38. scotthernandez –

    This is an amazing blend

  39. brianpatterson11 –

    Overall good, but proactive updates would help.

  40. Skyline883 –

    fine, nothing amazing but not bad either.

  41. Queen E –

  42. Ryan W –

  43. norma D –

  44. David Burr –

  45. Drako Daniel –

  46. Neo S –

    My order arrived two days earlier than expected, which was a pleasant surprise. The package was insulated with care, and the vials were organized neatly in individual baggies and they included reconstitution liquid for me which was a nice touch. I will be a loyal customer to this brand for sure. I tried other suppliers as well like Peptide Sciences but their credit processing crashes sometimes…

  47. james johnny –

    Fast service, no issues whatsoever. Always impressed with the quality here. Excellent quality and fast shipping. 📦

  48. mary J –

    Great experience ordering here. Fast service, no issues whatsoever.

  49. mary J –

    RELIABLE AND TRUSTWORTHY EVERY ORDER.

  50. George W –

  51. Howard –

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