Fragment 176-191 & CJC-1295 & Ipamorelin – 12MG
$92.00
Discount per Quantity
Quantity | Discount | Price |
---|---|---|
5 - 8 | 5% | $87.40 |
9 + | 10% | $82.80 |
Fragment 176-191 & CJC-1295 (Mod GRF 1-29) & Ipamorelin Blend
Growth hormone-releasing peptides (GHRPs), growth hormone secretagogues (GSHs) and other recombinant human growth hormone (rhGH) derivatives might be promising treatments for GH release. These two combined has been postulated by researchers to manifest significant activity. Enhanced fat metabolism, increased lean mass, regulation of sleep cycle, and improved intestinal and cardiac functioning are well known.
CJC-1295 is a synthetic peptide consisting of 29 amino acids. This peptide looks to function via activating the GHRHrehens in the pituitary. The natural GHRH binds to these receptors and usually provokes a reaction. CJC-1295 As mentioned CJC-1295 has, instead of simply being a piece of one of the GHRH strands, 4 amino acids (making it identical to the growth hormone that our brains produce,) taken away for purity and efficiency so that it causes less side effects than would be expected with a typical GHRH.
Ipamorelin is a synthetic pentapeptide that has been classified by researchers as a Growth Hormone Secretagogue (GHS) It has been suggested to work in the same manner as GHRPs and may also mimic the response of ghrelin, a naturally occurring hunger hormone which can increase hGH from cells in the anterior pituitary. To be specific, Ipamorelin could act like ghrelin in that area by binding to the ghrelin receptors there, also called the Growth Hormone Secretagogue receptors 1 Alpha (GHS-R1a.
As its name suggests, Fragment 176-191 peptide is a portion or fragment of the hGH growth hormone that is made up of 15 amino acids. This peptide would be a possible downstream weight loss inducer, perhaps targeting the beta-3 adrenergic receptors (ADRB3). In this manner, the peptide could enhance lipolysis within adipocytes by engaging these receptors, and might even upregulate 'thermogenesis' in skeletal muscle cells through a similar mechanism.
Taken together, this mix can stimulate a small portion of the pituitary gland which in turn can facilitate growth hormone secretion. Scientist have also suggested this blend might work together to increase and balance growth hormone level and ground degrees
Based on this research, it seems that fragment 176-191 is a direct receptor agonist to hGH while the peptides CJC-1295 and Ipamorelin are potential activators of the hGH production up-regulating it. By way of example, CJC-1295 has been the highlight of these products since it has shown some interesting potential to enhance hGH secretion during several phase-1 clinical trial.
The first included test subjects between the ages of 20 to 40. All subjects were assigned to one of two groups—the saline placebo group or the CJC-1295 peptide-treated group. Each subject had blood drawn before and after the peptide administration. The Researchers reported at the end of their study, that the peptide group had 7.5 times more growth hormone than the control group. This effect of trend implied a gradual increase in these hormones, which persisted for at least 7 days after the presentation had stopped.
The last study5 was with male participants between 20-60 years old. In a study similar to what has been previously described, these subjects were divided into two groups, one that were presented with placebo, while the others with CJC-1295 peptide. Peptide group was treated with compound at increased concentrations overtime as a part of the study. After examining the blood samples from these subjects, the concentration of growth hormones among peptide subjects seemed to rise according to dose with an increase of up to 10 times. Madalina Ionescu et al., "The impressive increase in trough GH levels following continuous GHRH stimulation suggests an important role of this effect in the IGF-I rise. Possibly, patients with GH secretory capability might benefit from long-acting GHRH preparations."
Similarly, Ipamorelin may also support hGH production. In a clinical study, it was theorized that one single administration of the peptide should increase hGH levels more than sixty fold greater than normal basal levels - without elevating blood sugar.
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