Matrixyl – 200MG
$184.00
Discount per Quantity
Quantity | Discount | Price |
---|---|---|
5 - 8 | 5% | $174.80 |
9 + | 10% | $165.60 |
Matrixyl
It has only recent begun to be scientifically investigated, but palmitoyl pentapeptide-4 (also called palmitoyl pentapeptide-3 or Matrixyl) is a synthetic peptide with claims it can increase skin collagen production. It could be called a matrikine (a messenger peptide which might be capable of interacting with their specific receptors to modulate cell activities). Collagen: a protein that is believed to have a role in supporting the flexibility and structural integrity of the skin extra cellular matrix. Conjugation with the palmitoyl also may allow for more uniformed delivery across the skin and more protection against degradation by cutaneous proteases.
Sundry studies indicate a limited potential for Matrixyl to stimulate fibroblasts and collagen synthesis. A study has even tested its potential in bi-lateral exposure research model at the same time with participants having their skin pricked half and half between Matrixyl peptide or placebo. The peptide is said in the study to have significantly decreased global wrinkle depth versus placebo control.
Another study set out to determine the influence of Matrixyl on cellular activities. A Matrixyl-containing compound was applied twice daily to the periorbital region of the research model over an 8-week period. Findings demonstrated efficacy from the Matrixyl group which demonstrated greater changes after treatment versus other peptides and placebo with the obtained measures.
One other study was to determine wrinkle-depth and surface skin texture on the periorbital region by Matrixyl. Two double-blind, randomized, placebo-controlled studies were performed in clinical models of moderate-severe periorbital wrinkles. At 4 weeks, researchers observed that the peptide seemed to have diminished the roughness of periocular skin and had decreased the visible depth of deeper wrinkles.
One such study examined the effects of Matrixyl on fibroblast contractility and how this might lead to scarring. Matrixyl appeared to decrease α-SMA (alpha-smooth muscle actin) protein expression and suppressed the conversion of fibroblasts into myofibroblast. Alpha smooth muscle actin (α-SMA), a protein that is expressed in normal smooth muscle cells, especially myofibroblasts, which play a key role in the pathogenesis of stricture formation in PJI model. This is also believed to be produced by a specific type of cell known as the myofibroblast that is essential for wound healing and tissue repair. In a setting of fibrotic scarring, myofibroblasts express α-SMA which correlates with collagen excess and scar tissue formation.
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