TB-500 – 5MG/10MG
$78.00 – $152.00
Discount per Quantity
| Quantity | Discount | Price |
|---|---|---|
| 5 - 8 | 5% | $74.10 – $144.40 |
| 9 + | 10% | $70.20 – $136.80 |
TB-500
The TB-500 peptide or synthetic Thymosin Beta 4 and Tβ4 is the synthetic form of the protein chain naturally produced by various animals including humans. The latter occurs in the thymus organ and is encoded by the TMSB4X gene. TB-500 peptide was proposed to carry the same potential as Thymosin beta 4 by many researchers. These proposed mechanisms of action would induce angiogenesis, enhance wound healing or enhanced metastatic potential of tumour cells and hair growth.
Additionally, TB-500 is a 43 amino acid peptide that is also highly water soluble and light in molecular weight with an abundance located in the wound fluid made up of multiple blood platelets. In addition, tumor necrosis factor mediating this neuroinflammatory response has also been recorded to be potentiated by this drug, which can increase its use for neurological healing as well as tissue repair in the spinal cord, which was shown to protect the heart where both organs required nootropic benefit with none developing osteoporotic psoriasis.
TB-500 peptide, referred to as thymosin β 4, includes a unique peptide sequence (17)LKKTETQ(23), which serves as the functioning region and researchers believe might be engaging in actin binding, cell migration, and wound healing. TB-500 Amino Acid Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Exen-Kohnu-Eugen-Reuh-Thr-Glu-Thr-Qelli-Eugen-Lys-Asn-Pro-Leu-Pro-Ser-Koen-Carmichael-Ile-Glu-Klein-Eugen-Klein-OH
Actins are a class of proteins that make up part of the cytoskeleton in cells and play crucial roles in maintaining cell shape and helping motives. In these cellular structures and processes, actin is proposed to play an important role. Thymosin beta-4 and is assumed to force interaction with actin and likely also binds to the globular form of actin, G-actin (the "Superglobule") which is the precursor step of filamentous actin phase F-actin. This interaction is thought to inhibit the conversion of G-actin into F-actin, a process called actin sequestration, and will thereby lead to more free copies of G-actin. Inhibition of F-actin formation by thymosin beta-4 may also conceivably act on the structural basis for modulation of cell cytoskeleton and subsequently affect cellular motility and morphological changes. The involvement of such changes in wound healing, tissue regeneration, and metastasis during cancer progression are suggested to make a tentative connection with physiology and pathophysiology states wherever motility of the cells is demanded.
In fact, thymosin beta-4 has been found inside cells and outside in, for example, blood plasma or wound exudates. In addition, a preliminary study of this vascular cells shows that Thymosin beta-4 is excreted outside the cell and may have a role in cell functionalities such as motivitation and angiogenesis (formation and new blood vessels). It is hypothesized that Thymosin beta-4 executes this ability at the cellular level via co-receptor functions related to ATP synthase enzymes localized on-cellular surfaces integral for energy production. These data clearly extend the range of activity of thymosin beta-4 into the extracellular compartment.
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