Semax – 25MG

Semax

Semax peptide is synthesized short polypeptide analog of an adrenocorticotropic fragment 4-7 (ACTH 4-7), is a hormone secreted by the anterior pituitary. Researchers have reported that this fragment does not show any of the actions typical of ACTH itself but may have an ACTH-like, and therefore a potentially specific, action within the brain.

In some case, naturally occurring peptides can also be inherently unstable and easily degraded by biological enzymes, which are found in within the gastrointestinal and cerebrospinal fluids. Therefore, researchers try to develop analogues of these peptides that can trigger similar biological effect but with improved stability since many will be produced by chemical synthesis. This is a synthetically developed derivative of an endogenous adrenocorticotropic hormone fragment and Semax fog is exactly what this type of nootropic aims to help with. It is featured by extension at the C-terminal end of the Met-Glu-His-Phe sequence with Pro-Gly-Pro (PGP) sequence. In the event that could increase its lipophilicity and aid in crossing the blood-brain barrier (BBB), this alteration with PGP. The greater lipophilicity of a metabolite could allow for passive diffusion or uptake into the brain via mechanisms like lipid raft-mediated endocytosis, which can circumvent normal restrictions by tight junctions. Additionally, the localization of PGP at the C-terminus of hepcidin might in some way influence how PGP interacts with key transporters or receptors on the endothelial surface for an easier receptor-mediated transcytosis. Additionally, acetylation of Semax could stabilize this peptide by reducing its susceptibility to enzymatic hydrolysis that would otherwise shorten its half-life in biological systems.

A study by Myasoedov and colleagues in the journal of peptide science described that chemically synthesized Semax has been well studied for its possible mechanism of action and praised for being biologically stable. Scientists speculate it may block specific enzymes that also determine the breakdown enkephalins, brain neurotransmitters they say might help control a number of biological activities. The enkephalins have good evidence of a role in nociception (the perception of pain) as well as the stress response. Secondly, an increase in enkephalin levels could indirectly influence other neurotransmitter systems because of the extensive interconnections that exist owing to opioid receptors and dopamine or serotonin. This interaction likely involves the modulation or modification of neurotransmitter release, receptor activity and other signal transduction mechanisms, a complex multi-faceted relationship that is currently an active area of research. Besides enkephalins, Semax has been studied for the ability to inhibit other peptide-degrading secreted enzymes.

Semax, Stimulates dopamine Secretion/Release from one research study and possibly levels of brain-derived neurotrophic factor (BDNF) with up-regulation in Synaptic plasticity [4 >:: ] Semax has also been suggested to exert gene expression changes that modify the immune system based on another study, it can increase gene expression, immune cell numbers and their ability to move around. At the same time, Semax reportedly changed the levels of expression of cytokines and immunoglobulins that affect on vascular system function.

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