MGF (Mechano Growth Factor) – 5MG

Mechano Growth Factor Peptide (MGF)

MGF or Mechano Growth Factor is a natural, endogenous peptide of the IGF-1 (insulin-like growth factor) family. MGF is a splice variant that contains 49 bp in the exon 5 of structural element compared to systemic IGF-1, which can cause a frame shit and results in special traits. Some researchers believe that MGF is an isoform of IGF-1 (IGF-1Ec, otherwise known as full-length MGF).

It appears that three isofroms are generated as a result of alternative splicing and transcription of IGF-1. IGF-1 performs splicing in stress conditions (for instance, after resistance activities) like those of muscle groups. This splicing and the 49 base pair insert, results in production of a mature peptide, IGF-1, which has either MGF or IGF-IEa peptides at the longstanding alternatively splic.

The phenomenon of IGF-1 splicing and isoform production was first proposed during the course of IGF-1 research studies. According to the researchers, the only common element for all three isoforms that could be identified as different from each other may be the amino acid sequence added to the COOH terminal. The novelty of the IGF-1Ec was only speculated in the late 1990s-early 2000 when it was hypothesized to be upregulated upon muscle injury.

MGF-Ct24E peptide is a synthetic analogue of MGF peptide consisting of C- terminally appended 24 amino acid E-domain (sequence corresponding to the C-terminal domain isolated from MGF), and belongs to the IGFs family essentially. With the studies conducted in 2000s, it was suggested that the MGF-Ct24E peptide, which can stimulate proliferation of muscle precursor cells. Satellite cells are adult muscle precursor cells that expand and then differentiate to form new muscles.

Similar to (IGF-1), MGF is expected to rise in response to increased availability of growth hormone, and may thereby be one of the main anabolic mediators responsible for GHs action. Growth hormones - Studies have suggested that over a short-term, growth hormones by itself can impact MGF expression up to around 80%, from the baseline. Comparison of muscle tissue from the two legs revealed that although no significant differences were detected in MGF mRNA as a result of heavy EMS, upregulation of MGF mRNA (163%) was seen in muscle tissue for resistance alone. Such a fast response may indicate that MGF is a more direct or sensitive responder to mechanical stimuli, though the site and level of such responsiveness are speculative. This response may also be augmented by a potential exercise-induced elevation of growth hormone, as reflected by an increased 456% in MGF mRNA following resistance training.

Science is still in the process of researching the means by which both the naturally existing and synthetically created MGF peptide operate. Some of the hypotheses potentially being explored abound are: whether or not this peptide could exert beneficial effects on injured muscle cells, tissue repair and recovery, neuroprotection, cardioprotection, regulation of apoptosis in muscle cells.

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