Livagen – 20MG

Livagen

It is a tetrapeptide containing lysine, alanine, aspartate and glutamate called livagen. This peptide is thought to be a bioregulator that can act upon the DNA structure, meaning it may affect regulation and function. The main capacity of Livagen is determined by its regulating effect at the level of chromatin, DNA and genes.

DNA, researchers formalized, is a double helix of the stuff wrapped in a shell made from wads of proteins named "histones. Chromosomes are made up of histones, which come together to create a chromatin, while several chromatins come together to form the chromosomes. These chromosomes seem important for genetic specifics to each organism.

These chromatin materials have long been eyed by researchers as potential targets for Livagen, which is being designed to 'de-condense'. When that happens, some of the genes that had gone dormant may turn back on, and this could boost cell function as well as numbers. According to researchers, Livagen could elevate levels of energy and skin elasticity as well have positive effects on immune functionality led by such mechanism.

These researchers suspect that the lipid peptide specifically targets the lymphocytes, reactivating ribosomes by 'unpacking' chromatin and subsequently altering gene expression. These white blood cells are known to play an important role in defense against invading impurities and contribute to immune power. Consequently, Livagen could have capacity to increase the body immune system by modulating cellular responses and regulating immune response. A clinical study conducted by T. Lezhava et al. reported that “These data suggest that peptide bioregulators Epitalon, Livagen and Vilon lead to chromatin activation (deheterochromatinization) in lymphocytes of [aged models].

Cardiac disorders including hypertrophic cardiomyopathy (HCM), coronary artery disease and myocardial injury have been correlated with impaired gene expression and chromatin remodeling. Livagen is a bioregulatory peptide suggested by researchers to induce the possibility of reverse engineering the gene regulation dysfunctions. In cell culture models of HCM, Livagen peptides have been shown to reduce the specific long-term consequences research suggesting that its peptides could help mitigate such effects in heart cells exhibiting characteristics of the condition in Patients who suffer conditions that underlie it3-7. There was also another publication from this study on the possible effect of their combined exposure to peptides in the presence of cobalt ions for testing whether they might promote or transduce chromatin structures related to hypertrophic cardiomyopathy (HCM, experimental models). Schematic diagram that this combination may induce chromatin de-condensation according to the study According to the researchers, the findings of this study are significant “due to the discovery of a new action mechanism of elements in Livagen and Livagen plus Cobalt ions that protect lymphocytes” in hypertrophic cardiomyopathy models. It was suggested that Livagen, used alone or together with cobalt ions, might influence NOR and acrocentric chromosomes association (Index of the Volume 44% ). The use of Livagen and cobalt ions in combination enhances the frequency to 2 NORs, important for ribosomal RNA synthesis according to the study These different actions on NORs by Cr may suggest changes in protein synthesis which, modification of synergistic mechanisms in translation might be important to understand the regulation that transforms cellular function into those seen in cardiac hypertrophy associated with HCM. Moreover, there was a significant elevation in the frequency of associations of acrocentric chromosomes, suggested to be higher under joint effect by Livagen and cobalt ions than separate actions of each agent. This is consistent with alterations in the chromatin state, including an increase in decompaction of heterochromatin. This chromatin remodeling might enhance the exposure and perhaps transcriptional activation of genes which have been inactivated within these regions, according to this study.

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